Cholecystokinin Metabolism in Man and Dogs

Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.

The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans. Thirty-two physically active men were randomly assigned in a double-blind manner to either a normoxic (N; n = 14) or hypoxic (H; n = 18) group. During the acute study, subjects in the H group only participated in two tests, ...

Cholesterol metabolism in man.

It has been previously demonstrated that, in the rat, the major metabolic pathway of cholesterol involves the conversion of this molecule to bile acids (1, 2). These are excreted into bile and after repeated enterohepatic circulation (3) are finally eliminated in the feces, still in the form of bile acids. Over 80 per cent of the body's cholesterol was found to be metabolized in this manner (1,...

Pyrimidine metabolism in man.

Tryptophan Metabolism in Man.

The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...

C-terminal octapeptide of cholecystokinin decreases food intake in man.

In comparison with a saline infusion, the infusion of the C-terminal octapeptide of cholecystokinin (4 ng/kg/min) decreased food intake by an average of 122 g in a group of 12 lean men without objective evidence of untoward side effects. Shapes of the cumulative intake curves under the two conditions were similar, but subjects ate less and stopped eating sooner when receiving octapeptide than w...